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Research

We forecast social, health, and infrastructure outcomes by modeling complex scenarios

How can we best fight infectious disease outbreaks? When will a social media protest become a civil crisis? We investigate large-scale biological, social, and technological systems at play in the world. By simulating scenarios of unfolding situations, we provide insights to help decision-makers refine science-based responses. In the process, we produce high-tech tools and foundational knowledge that advance the science of biocomplexity.

Areas of Focus

We apply our computational modeling tools and combined expertise to tackle a broad swath of issues affecting human life – from improving disaster resiliency in city infrastructures to identifying previously unknown organisms in our environments and bodies.

We develop tools to distill vast medical and ecological data and share them with research scientists, healthcare professionals and policymakers.

By computing predictive models, we provide public-health policymakers with data and analysis to identify and respond to epidemics.

We explore the information content in structured sequence data to reveal how changes in one influence the time evolution of the other. This contributes unique insights into viral dynamics at the host population level.

We investigate the structure of large bio-networks such as long noncoding RNA molecules. This contributes to the understanding of cancer development.

We study the abstraction to shape of a biological system - using it as a mathematical language to measure its complexity of interaction and provide ways of decomposing it into more fundamental blocks. This contributes to the understanding of ncRNA and structure switching.

Tackling community issues such as economic mobility and improving access to food, housing, and jobs to advance community health and well-being.

Improving the well-being of citizens across the nation through the health of our national systems from food to defense to technology.

Assessing the use of non-survey data flows to supplement or enhance current development of Official Statistics.

Research Spotlight

Modeling for COVID-19

We've modeled several epidemics in the past 20 years, including H1N1 and Ebola. Today, collaborating with researchers from across the Institute and the University of Virginia, we're modeling scenarios to help governments and the global research community understand and mitigate the spread of COVID-19.

Student Opportunities

Computing for Global Challenges Program

From human health to infrastructure, our world is facing enormous threats. To understand them, we need and use data. This undergraduate program is a training ground for the next generation of data-driven researchers. Working in teams with peers and scientists from the Institute's Network Systems Science and Advanced Computing division, students learn a new way to address real-world issues while working on critical research projects.

All Projects

Epidemiological models predict the spread of highly contagious and lethal diseases such as COVID-19. Public health officials use such models to inform pandemic response policies and advisories. Yet these models require a rigorous scientific foundation in human psychology to better predict people’s responses to information and policies about pandemics. The recent COVID-19 pandemic illustrates the central role of human decision-making and behavior in the spread of such a transmissible disease. Decisions regarding social isolation, social distancing, mask-wearing, hand washing, and vaccination are correlated with the rate at which the COVID-19 virus spreads or the seriousness of getting infected. People with diverse individual mindsets can vary across different regions and subgroups, so different groups of people can vary across different regions and subgroups, so different groups respond differently to messaging and mandates and those responses change over time. There is also an ongoing scientific debate about the degree to which pandemic information or misinformation, and the perceived credibility of information sources influences the degree to which people change their behavior. To address these scientific needs, this project involves activities to develop a multidisciplinary research core and agenda as well as a strong plan for a cohesive research center for Predictive Intelligence for Pandemic Prevention. The activities include exploratory research on computational models of human psychology, information flow and influence, and resulting pandemic transmission. The project will also support the training and mentoring of graduate students who represent the next generation of researchers tackling these global challenges.
PREPARE is a virtual organization to facilitate communication and collaboration among scientists currently involved in pandemic research through the NSF RAPID program. With the guidance of a Steering Committee composed of members from industry, academia, and government agencies, PREPARE will encourage the sharing of research results in a way not available without a concerted effort.
This work aims to enhance existing health damage estimation methods used in economic analyses to inform environmental decision-making activities.